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:: Volume 5, Issue 4 (Vol.5, No.4, Winter 2018) ::
J Neyshabur Univ Med Sci 2018, 5(4): 22-31 Back to browse issues page
Protective Effect of Royal Jelly on Liver Tissue in Nicotine-treated Adult Female Rats
Zhila Khodabandeh *1, Vahid Nejati2, Gholamreza Najafi2, Ali Shalizar Jalali2, Fateme Rahmani2
1- university , khodabandeh.zhila@yahoo.com
2- university
Abstract:   (2255 Views)
Introduction: Nicotine is a nitrogenous organic compound and an active ingredient in a cigarette. This substance is toxic for cardiovascular, nervous and respiratory systems and various tissues of the body. In the present study, the protective role of royal jelly as an antioxidant on nicotine-induced liver histological changes and oxidative damages was investigated in rats.
Materials and Methods : In this study, 56 adult female  rats were used  and  divided into 8 groups (n = 7) including group 1: control, groups 2,3 and 4: nicotine treatment respectively at a dose of 0.50,1 and 2 mg/kg body weight, Group 5: royal jelly administration at a dose of 100 mg/kg bw, Groups 6,7 and 8: 0.50,1and 2 mg/kg bw nicotine respectively with 100 mg/kg bw royal jelly. Nicotine and royal jelly were administered daily for 49 days in experimental groups intraperitoneally and orally, respectively. At the end of experimental period, serum and tissue samples were provided and used for serological and histological analyses. Data were analyzed by one-way ANOVA and Tukey statistical tests using SPSS software.
Results: Royal jelly attenuated oxidative stress and serum levels of aspartate aminotransferase , alanine aminotransferase and alkaline phosphatase as well as hepatic tissue damages in nicotine-treated groups.
Conclusion: Royal jelly can have a protective effect on hepatic tissue of nicotine-treated rats.
Keywords: Nicotine, Liver, Royal Jelly, Rat
Full-Text [PDF 711 kb]   (562 Downloads)    
Type of Study: Orginal Article | Subject: Pathology
Received: 2017/08/8 | Revised: 2018/05/20 | Accepted: 2017/12/13 | Published: 2018/05/13 | ePublished: 2018/05/13
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Khodabandeh Z, Nejati V, Najafi G, Shalizar Jalali A, Rahmani F. Protective Effect of Royal Jelly on Liver Tissue in Nicotine-treated Adult Female Rats. J Neyshabur Univ Med Sci. 2018; 5 (4) :22-31
URL: http://journal.nums.ac.ir/article-1-378-en.html

Volume 5, Issue 4 (Vol.5, No.4, Winter 2018) Back to browse issues page
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