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The effect of combined training on ABCG1 gene expression in mononuclear cells after coronary artery bypass surgery in middle aged men
Rokhsareh Feyollah zadeh moosavi Mrs1 , Amir Rashidlamir Mr * 2, Rambod Khajei Mr1 , Mahmood Hejazi Mr3
1- Department of Physical Education, Neyshabour Branch, Islamic Azad University, neyshabour, Iran
2- Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran , Amir.Rashidlamir@gmail.com
3- Department of Exercise Physiology, Faculty of Sport Sciences, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Abstract:   (90 Views)
Introduction
The present study purposed to investigate the effect of combined exercise and cardiac rehabilitation in mononuclear cells on ABCG1 gene expression in middle-aged men after coronary artery bypass graft surgery.
Materials and Methods
The statistical population of this study was 30 middle-aged male patients who previously had coronary artery bypass surgery. The subjects were randomly assigned into two groups: control (C; n=15), combined training (endurance and resistance training, ERT; n=15). Blood draws occurred prior to and after training sessions. After isolating monoclonal cell lines using ficoll and purifying mRNA, gene expression changes were done using Real-Time PCR. Data were analyzed by repeated sampling (SPSS software version 16).
Results
Eight weeks of combined exercise resulted in a significant increase in mRNA expression of the ABCG1 gene in ERT group compared to the C group.
Conclusion
Combined training as a part of the cardiac rehabilitation process in the patients undergoing coronary artery bypass graft surgery, by affecting the expression of the ABCG1 gene in the lipid metabolism, appears to augment the process of reverse cholesterol transfer.
Keywords: coronary artery bypass graft surgery, ABCG1, Combined exercise.
     
Type of Study: Orginal Article | Subject: Physiology
Received: 2018/10/20 | Revised: 2019/09/4 | Accepted: 2019/07/1 | ePublished ahead of print: 2019/08/26
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مجله علوم پزشکی نیشابور J Neyshabur Univ Med Sci

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