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The Effect of Resistance Training on Protein-D Surfactant and Insulin Resistance Index in Healthy and Type 2 Diabetic Rats
Mohamm Parastesh Mr * 1, Abbas Saremi Mr2 , Abbas Salehikia Mr3
1- Arak University , mohamad.parasteah@gmail.com
2- Arak University
3- University of Sistan and Baluchestan, Zahedan, Iran.
Abstract:   (142 Views)
Protein-D Surfactant (SPD) is a new factor associated with glucose intolerance, insulin resistance and type 2 diabetes.The aims of present study was to investigate effects of resistance training on surfactant protein-D in streptozotocin–nicotinamide induced diabetic rats.
Materials and Methods
In this experimental study، 48 adult male Wistar rats in the weight range of 200±48gr, randomly assigned in to four groups: healthy control, diabetic control, diabetic resistance training and healthy resistance training. For induction of diabetes, intraperitoneal injection of nicotinamide solution  and STZ solution was used. The training groups performed a resistance training program for 10 weeks.Data were analyzed using one-way ANOVA and Tuky  Post Hoc test at 0.05%.
Resistance training caused a significant decrease in blood glucose in the resistance diabetic training group compared to the diabetic control group (P=0.024). Serum Protein-D Surfactant (SPD) serum levels in the diabetic control group significantly decreased (P=0.042) and the insulin resistance index (P=0.024) was significantly lower than healthy controls. 8 weeks of endurance training significantly increased in SPD in endurance diabetic training group compared to diabetic control group (P=0.043). Also, exercise significantly decreased insulin resistance index (P=0.034) and insulin in endurance diabetic training group compared to diabetic control group (P=0.046).
The results of this study seem to confirm the role of Protein-D Surfactant associated with resistance training in improving insulin resistance index in type 2 diabetic rats.
Keywords: Rat, Streptozotocin–nicotinamide, SPD, Insulin, Resistance training.
Type of Study: Orginal Article | Subject: Physiology
Received: 2018/12/31 | Revised: 2019/04/7 | Accepted: 2019/04/11 | ePublished ahead of print: 2019/05/21
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