[Home ] [Archive]   [ فارسی ]  
:: ::
Back to the articles list Back to browse issues page
The effect of silver nanoparticle toxicity on the inflammatory markers of heart tissue following an anaerobic training course in male wistar rats
Forogh Javaheri hoshi Dr , Asieh Abbassi daloii Dr * 1, Ahmad Abdi Dr , Seyed javad Ziaolhagh Dr
1- , a.abdi58@gmail.com
Abstract:   (97 Views)

Exposure to nanoparticles toxicity leads to impairment of heart function and increases inflammatory cytokines. The purpose of this study was to investigate the effect of silver nanoparticle toxicity on the inflammatory markers of heart tissue following an anaerobic training course in male wistar rats.

Materials and Methods

In this experimental study, 30 male Wistar rats aged 8 to 12 weeks and weighing 202±34.9 gr were randomly divided into 6 groups include of control, anaerobic training, anaerobic training - nano biological, anaerobic training - nanochemical, nano-biological and nanochemical. Chemical and biological silver was injected intraperitoneally after a period of anaerobic training. The specimens were discarded after 48 hours, and the heart tissue was removed.

Results

The results showed that ICAM, hsCRP, IL-8 and IL-6 levels of male Wistar rats were different in groups (P=0.000). The hsCRP concentration of heart tissue was significantly lower in the Nanochemical - anaerobic and Nanobiological - anaerobic training group compared to Nanochemical and Nanobiological groups respectively (P=0.000). Also, IL-8 of heart tissue was significantly lower in the Nanochemical - anaerobic group compared to the Nanochemical group (P=0.000).

Conclusion

The toxicity of silver nanoparticles was associated with an increase in inflammatory markers in the heart tissue. It seems regular anaerobic training may have a protective effect against the increase some of the inflammatory factors due to the toxicity of chemical and biological silver nanoparticles.

Keywords: Silver Nanoparticles, Exercise, Inflammatory parameters, Heart Tissue, Rats
     
Type of Study: Orginal Article | Subject: Physiology
Received: 2019/06/15 | Revised: 2019/08/6 | Accepted: 2019/08/13 | ePublished ahead of print: 2019/08/26
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print



Back to the articles list Back to browse issues page
مجله علوم پزشکی نیشابور J Neyshabur Univ Med Sci

*** هرگونه کپی برداری از این سایت بدون ذکر منبع غیر قانونی و همراه با پیگیری های قضایی می باشد *** مجله دانشکده علوم پزشکی نیشابور *** Any copying of this site without citing the source is illegal And is associated with the pursuit of justice ***

Persian site map - English site map - Created in 0.14 seconds with 31 queries by YEKTAWEB 3960