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The effect of Vitex Agnus castus extract on blood level of prolactin, & compare of its effects on the Lipids level with those of Bromocriptine and Dostinex in women with hyperprolactinemia
Naiyereh Haerifar1, Ghoamhassan Vaezi Dr. *2, Zahra Ghatreh Samani Dr.3, Shaker Salari lak Dr.4
1- department of Biology,Damghan Branch,Islamic Azad University,Damghan,Iran
2- department of Biology,Damghan Branch,Islamic Azad University,Damghan,Iran , naiyereh.haerifar@gmail.com
3- department of Gynaecology,Tabriz Branch,Islamic Azad University, Tabriz,Iran
4- Department of Public Health, Tabriz Branch, Islamic Azad University, Tabriz, Iran
Abstract:   (499 Views)
Hyperprolactinemia in women results to menstrual disorders, irregular ovulation, amenorrhea and reduction of progesterone Level after ovulation, due to corpus luteum failure. This study aimed at comparing the effect of Vitagnus fruit extract on blood prolactin level and its effect on altered serum lipids in Hyperprolactinemic women with Bromocriptin and Dustinex.
Among the women with Hyperprolactinemia referring to medical Centers, 105 subjects were chosen and classified into 3 groups: Bromocriptin Dustinex and Vitagnus. They were treated with during (i.e. 4 cycles), and finally the blood levels of prolactin, Cholesterol, HDL, LDL, triglycerides were measured.
The results showed that, except in Bromocryptin, in other groups, there were meaningful difference in each step compared to earlier step in terms of prolactin level change.
In Bromocryptin group, after two cycles of treatment, each step showed meaningful difference with the earlier step (p<0.05). examination of cholesterol level showed that the reduction of cholesterol level in Various cycles, was meaningful. In Dustinex group, there was observed meaningful difference in all steps except final step of treatment. In the case of Vitagnus, the impact of treatment was meaningful, except in the first step.
The results showed that all drugs had meaningful effect on LDL level, after the third stage. The increase in serum HDL level for Vitagnus was more than other Tablets in all stages.
Vitagnus decreases the prolactin level meaningfully, Similar to Bromocryptin and Dustinx. Also decreased cholesterol, LDL, and triglyceride, wherever increased HDL level.
 
Keywords: Vitagnus, Prolactin, Lipids, Bromocriptine, Dostinex
     
Type of Study: Orginal Article | Subject: biology
Received: 2019/10/12 | Revised: 2020/05/30 | Accepted: 2020/05/20 | ePublished ahead of print: 2020/06/17 | Published: 2020/05/30 | ePublished: 2020/05/30
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