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Assessment of memory function of offspring rats born to mothers under treating with buprenorphine during pregnancy and lactation
Saeed Samarghandian Dr. , Omid Mehrpour Dr. , Moshen Foaddini Dr. , Babak Roshanravan Dr. , Tahereh Farkhondeh Dr. 1
1- , farkhondeh2324@gmail.com
Abstract:   (181 Views)
Introduction: Buprenorphine is an opioid drug that is prescribed as an opioid maintenance therapy for addiction during pregnancy and lactation, but its adverse effects on the fetus and infant have not been well studied. Therefore, in the present study, we investigated the effect of buprenorphine administration during pregnancy and lactation on the memory function of offspring animals.
Method: 30 female rats in gestation and lactation stages are allocated in the controls, gestation and lactation treat groups. After parturition, dams and their pups were kept in one cage during lactation without BUP administration. After parturition, other groups subcutaneously receiving one dose of vehicle as a control group, and lactation treat group (0.5 and 1 BUP) subcutaneously receiving BUP 0.5 and 1 mg/kg once a day and pups are weaned on postnatal (PN) day 28. Six offspring from each group were randomly selected to evaluate the memory function. The spatial memory function was checked using the Y-maze test.
Results: In this study, there was no significant difference between the groups exposed to buprenorphine in the embryonic and breastfeeding period and the control group in the alternative percentage.
Conclusion: The present study showed that exposure to buprenorphine in the fetal and infant stage has no effect on the spatial memory function, but this study does not confirm the safety of this drug and further studies are needed to show the effect of buprenorphine on cognitive function.
Keywords: Buprenorphine, memory, fetal period, lactation, memory function test
Type of Study: Orginal Article | Subject: Pharmacy
Received: 2020/07/7 | Revised: 2020/11/19 | Accepted: 2020/11/22 | ePublished ahead of print: 2021/01/23
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مجله علوم پزشکی نیشابور J Neyshabur Univ Med Sci

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