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:: Volume 6, Issue 1 (Vol.6, No.1,Spring 2018) ::
J Neyshabur Univ Med Sci 2018, 6(1): 70-80 Back to browse issues page
Effects of aerobic training with coriander seed extract on serum paraoxonase-1, TNF-α, and CRP in diabetic rats
Ahmad Abdi Dr 1, Zinab Sheykholeslami MS2 , Azadeh Ghorbani hasan saraee Dr3 , Hajar Abaszadeh Dr3 , Parvin Farzanegi Mr4 , Zakie Sheykholeslami MS5
1- Assistant Professor Islamic Azad University , a.abdi58@gmail.com
2- pHD student Islamic Azad University
3- Assistant Professor Islamic Azad University
4- Associate Professor Islamic Azad University
5- Masters Islamic Azad University
Abstract:   (106 Views)
Introduction
The main purpose of this study was to investigate the effects of aerobic training with coriander seed extract on serum paraoxonase-1, TNF-α, and CRP in diabetic rats.
Materials and Methods
40 Diabetic male Wistar rats (8 weeks old; weight: 130 ± 10 g) were randomly divided into four groups: control, extract, training, and training-Extract. Diabetes was induced by using Streptozotocin. Rats were selected as diabetic, with fasting blood glucose 126-400 mg/dl. The extract was administered orally (150 mg/kg/day). The exercise program was six weeks, 5 times a week with 50-55% of maximal oxygen consumption. The data were analyzed using of one-way ANOVA and Tukey test at α<0.05.
Results
Aerobic training with coriander seed extract increased serum paraoxonase-1 (P = 0.000) and HDL (P = 0.000). It also decreased TNF-α (P = 0.017), CRP (P = 0.014),   TG (P = 0.007), TC (P = 0.029) and LDL (P = 0.012) in diabetic male rats. We, then applied, post hoc test, it showed that a significant difference between the groups at the level of this profile.
Conclusion
 Six weeks of regular aerobic training with coriander seed extract have been shown to increase paraoxonase-1 and decrease levels of TNF-α and CRP in diabetic rats, and possibly moderates the risk of atherosclerosis in type 2 diabetes.
Keywords: exercise, coriander, vascular injury, inflammatory profile, Lipid profile
Full-Text [PDF 1312 kb]   (33 Downloads)    
Type of Study: Orginal Article | Subject: Physiology
Received: 2018/02/17 | Accepted: 2018/07/2 | Published: 2018/09/9
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Abdi A, sheykholeslami Z, Ghorbani hasan saraee A, abaszadeh H, farzanegi P, sheykholeslami Z. Effects of aerobic training with coriander seed extract on serum paraoxonase-1, TNF-α, and CRP in diabetic rats. J Neyshabur Univ Med Sci. 2018; 6 (1) :70-80
URL: http://journal.nums.ac.ir/article-1-494-en.html


Volume 6, Issue 1 (Vol.6, No.1,Spring 2018) Back to browse issues page
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