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:: Volume 6, Issue 3 (Vol.6, No.3,autumn 2018) ::
J Neyshabur Univ Med Sci 2018, 6(3): 87-101 Back to browse issues page
Effect of combined therapy with resveratrol, continuous and interval exercises on oxidative stress and inflammation in cardiac tissue of male rats with non-alcoholic fatty liver
Hossein Mahdian Mr1 , Parvin Farzanegi Dr * 2, Amin Farzaneh hesari Dr1
1- Islamic Azad University
2- Islamic Azad University , parvin.farzanegi@gmail.com
Abstract:   (770 Views)
Background and objective: Non-alcoholic fatty liver (NAFLD) is the most important liver chronic disorder. In this study, combined therapy with resveratrol supplementation alone or in combination with exercise training was considered on oxidative stress status and inflammatory biomarkers in the heart of rats with NAFLD. 
Background and objective: Non-alcoholic fatty liver (NAFLD) is the most important liver chronic disorder. In this study, combined therapy with resveratrol supplementation alone or in combination with exercise training was considered on oxidative stress status and inflammatory biomarkers in the heart of rats with NAFLD. 
Materials and methods: In this experimental study a total of 56 male rats were divided into two groups, including control (n=7) and NAFLD (n=49). NAFLD was induced using high-fat diets and then the NAFLD rats were randomly divided into seven experimental groups including, patient, saline, resveratrol (RSV), continuous exercise, interval exercise, continuous exercise + RSV, and interval exercise + RSV. Oxidative stress and inflammation biomarkers, including superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), IL-10, and TNF-α were measured in the heart tissue using specific ELISA kits.   Data were analyzed using ANOVA program by SPSS software.
Results: Resveratrol supplementation alone or in combination with exercise training significantly increased the mean of cardiac CAT and SOD activity compared to the patient and saline groups (p<0.0001), while MDA level was significantly decreased (p<0.05). Furthermore, RSV alone or in combination with exercise training significantly decreased the TNF-α content, but significantly increased the IL-10 level in the heart tissue (p<0.001).
Conclusion: NAFLD is associated with oxidative stress and inflammation in the heart tissue. Although resveratrol alone has an anti-oxidative and anti-inflammatory property, combined therapy with interval and continuous training can be probably more effective.
Keywords: Oxidative Stress, Non-alcoholic Fatty Liver, Interval and Continuous Trainings, Resveratrol, Heart, Wistar Rats
Full-Text [PDF 1392 kb]   (269 Downloads)    
Type of Study: Orginal Article | Subject: Physiology
Received: 2018/07/8 | Revised: 2019/01/16 | Accepted: 2018/10/15 | ePublished ahead of print: 2018/12/15 | Published: 2018/12/27 | ePublished: 2018/12/27
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mahdian H, farzanegi P, farzaneh hesari A. Effect of combined therapy with resveratrol, continuous and interval exercises on oxidative stress and inflammation in cardiac tissue of male rats with non-alcoholic fatty liver. J Neyshabur Univ Med Sci. 2018; 6 (3) :87-101
URL: http://journal.nums.ac.ir/article-1-560-en.html


Volume 6, Issue 3 (Vol.6, No.3,autumn 2018) Back to browse issues page
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