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:: Volume 7, Issue 2 (Vol.7, No.2,Summer 2019) ::
J Neyshabur Univ Med Sci 2019, 7(2): 88-100 Back to browse issues page
The effect of resistance training on protein-D surfactant and insulin resistance index in healthy and type 2 diabetic rats
Mohamm Parastesh Mr * 1, Abbas Saremi Mr2 , Abbas Salehikia Mr3
1- Sport physiology and Injury group, Faculty of Sport Sciences, Arak University, Arak, Iran , mohamad.parasteah@gmail.com
2- Sport physiology and Injury group, Faculty of Sport Sciences, Arak University, Arak, Iran
3- Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran
Abstract:   (823 Views)
Introduction
Protein-D Surfactant (SPD) is a new factor associated with glucose intolerance, insulin resistance, and type 2 diabetes. The aim of the present study was to investigate the effects of resistance training on surfactant protein-D in streptozotocin-nicotinamide-induced diabetic rats.
Materials and Methods
In this experimental study، 48 adult male Wistar rats in the weight range of 200±48gr, randomly assigned into four groups: healthy control, diabetic control, diabetic resistance training, and healthy resistance training. For induction of diabetes, intraperitoneal injection of nicotinamide solution and STZ solution was used. The training groups performed a resistance training program for 10 weeks. Data were analyzed using one-way ANOVA and Tuky  Post-hoc test at 0.05%.
Results
Resistance training caused a significant decrease in blood glucose in the resistance diabetic training group compared to the diabetic control group (P=0.024). Serum Protein-D Surfactant (SPD) serum levels in the diabetic control group significantly decreased (P=0.042) and the insulin resistance index (P=0.024) was significantly lower than healthy controls. 8 weeks of endurance training significantly increased in SPD in endurance diabetic training group compared to diabetic control group (P=0.043). Also, exercise significantly decreased insulin resistance index (P=0.034) and insulin in endurance diabetic training group compared to diabetic control group (P=0.046).
Conclusion
The results of this study seem to confirm the role of Protein-D Surfactant associated with resistance training in improving insulin resistance index in type 2 diabetic rats.
Keywords: Rat, Streptozotocin–nicotinamide, SPD, Insulin, Resistance training.
Full-Text [PDF 1662 kb]   (164 Downloads)    
Type of Study: Orginal Article | Subject: Physiology
Received: 2018/12/31 | Revised: 2019/07/6 | Accepted: 2019/04/11 | ePublished ahead of print: 2019/05/21 | Published: 2019/07/6 | ePublished: 2019/07/6
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Parastesh M, saremi A, Salehikia A. The effect of resistance training on protein-D surfactant and insulin resistance index in healthy and type 2 diabetic rats . J Neyshabur Univ Med Sci. 2019; 7 (2) :88-100
URL: http://journal.nums.ac.ir/article-1-637-en.html


Volume 7, Issue 2 (Vol.7, No.2,Summer 2019) Back to browse issues page
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