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:: Volume 8, Issue 2 (Vol.8, No.2,Summer 2020) ::
J Neyshabur Univ Med Sci 2020, 8(2): 118-131 Back to browse issues page
The Effect of Eight-week Concurrent Training On The Plasma And Gene Expression Levels VEGFR-1 and VEGFR-2 in Men with Prostate Cancer
Marzieh beigom Hejazian Miss1 , Alireza Barari Dr * 2, Asieh AbbasiDaloii Dr1 , Kambiz Hasrak Dr3
1- Department of Exercise Physiology, Ayatollah Amoli branch, Islamic Azad University, Amol, Iran
2- Department of Exercise Physiology, Ayatollah Amoli branch, Islamic Azad University, Amol, Iran , alireza54.barari@gmail.com
3- Department-Molecular Genetics Laboratory, Baqiyatallah El - Azam Subspeciality Hospital, Tehran, Iran
Abstract:   (679 Views)
Introduction
physical activity has been considered as an effective intervention of prostate cancer treatment strategies by modulating angiogenesis in the tumor. The aim of this study was to investigate the effect of eight-week concurrent training on the plasma and gene expression levels of VEGFR-1 and VEGFR-2 of men with prostate cancer.
Materials and Methods
In this clinical trial study, 20 men with prostate cancer (age = 62/2 ± 5/69 years old, stage 1 & stage 2) were randomly selected of Baqiyatallah al-Achr('39')zam sub-hospital in Tehran and Patients were divided into two groups of experimental and control. The experimental group performed 8 weeks training including 3 sessions/week. The workouts were the combination of exercises with resistance and endurance training per session as 60-75%, one-repetition maximum, and 60-75% of maximum heart rate. The Blood samples were tested for VEGFR-1 and VEGFR-2 using ELISA and Real-Time PCR methods, respectively, and the data were analyzed using dependent and independent t-test at the significant level p≤0/05.
Results
The results showed that the effect of eight-week concurrent training significantly decreased in BMI (p=0/001) and a significant increase in Vo2peak (p≤0/005) and strength (p≤0/001) the experimental group. Also, significantly decreased plasma levels (p≤0/007) and expression of VEGFR-1 and VEGFR-2 gene (p≤0/03 & p≤0/04) the experimental group compared with control group (P <0.05).
Conclusion
Considering the importance of VEGFR-1 and VEGFR-2 as the main intermediaries of cell signal transduction for angiogenesis and tumor extension, probably the effect of eight-week concurrent training by modifing angiogenesis of tumor microenvironment can be effective in reducing the progression of prostate cancer.
Keywords: Angiogenesis, Exercise training, Prostate cancer, VEGFR-1, VEGFR-2
Full-Text [PDF 1507 kb]   (78 Downloads)    
Type of Study: Orginal Article | Subject: Physiology
Received: 2019/01/30 | Revised: 2020/09/18 | Accepted: 2020/05/19 | ePublished ahead of print: 2020/06/7 | Published: 2020/05/30 | ePublished: 2020/05/30
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hejazian M B, barari A, AbbasiDaloii A, Hasrak K. The Effect of Eight-week Concurrent Training On The Plasma And Gene Expression Levels VEGFR-1 and VEGFR-2 in Men with Prostate Cancer. J Neyshabur Univ Med Sci. 2020; 8 (2) :118-131
URL: http://journal.nums.ac.ir/article-1-670-en.html


Volume 8, Issue 2 (Vol.8, No.2,Summer 2020) Back to browse issues page
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