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:: Volume 8, Issue 1 (Vol.8, No.1,Spring 2020) ::
J Neyshabur Univ Med Sci 2020, 8(1): 115-126 Back to browse issues page
Aerobic training prevents the obesity-induced cardiovascular disorders: focus on betatrophin and irisin levels
Abbas Saremi Dr 1, Mohammad Parastesh Dr2
1- arak university , a-saremi@araku.ac.ir
2- arak university
Abstract:   (2564 Views)
Introduction: Betatrophin and irisin are a liver and muscle tissue produced proteins that regulate the triglyceride metabolism as well as glucose homeostasis. This study was designed to evaluate the level of betatrophin and irisin in obese rats before and after aerobic training. Materials and Methods: Twenty four, 8-week-old male Wistar rats (249.8±11.2g) were selected and purchased for the research. After obesity induction by high-fat diet, the animals were randomly divided into two groups: exercise (n = 12) and control (n = 12). Also a match group with normal weight was selected for baseline comparisons. The animals trained 60 min/day, 5 days/week for 10 weeks. Body weight, lipid and glycemic profiles, and betatrophin and irisin levels were assessed after 10 weeks of training.  The data were compared using analysis of variance (P<0.05).
Results: Results showed that weight mass (P<0.01), plasma total cholesterol (P<0.02), triglyceride (P<0.05) and fasting glucose (P<0.04) were reduced in obese rats following the exercise training. Plasma betatrophin was significantly reduced in exercise compared to sedentary groups (P<0.02). Conversely, irisin concentration was significantly elevated with exercise (P<0.03).
Conclusion: The data demonstrated that moderate intensity aerobic training prevented obesity-induced cardiovascular disorders simultaneously with improvements in betatrophin and irisin levels in obese rats.
Keywords: Aerobic exercise, betatrophin, metabolic syndrome, myokine
Full-Text [PDF 1083 kb]   (323 Downloads)    
Type of Study: Orginal Article | Subject: Physiology
Received: 2019/02/27 | Revised: 2020/05/10 | Accepted: 2019/08/31 | ePublished ahead of print: 2019/12/10 | Published: 2020/05/10 | ePublished: 2020/05/10
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saremi A, parastesh M. Aerobic training prevents the obesity-induced cardiovascular disorders: focus on betatrophin and irisin levels. J Neyshabur Univ Med Sci. 2020; 8 (1) :115-126
URL: http://journal.nums.ac.ir/article-1-692-en.html

Volume 8, Issue 1 (Vol.8, No.1,Spring 2020) Back to browse issues page
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