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:: Volume 8, Issue 1 (Vol.8, No.1,Spring 2020) ::
J Neyshabur Univ Med Sci 2020, 8(1): 46-59 Back to browse issues page
The effect of six weeks of increasing endurance training and consumption of L-carnitine on BAX / BCL-2 and oxidative stress indices in the heart tissue of diabetic rats
Meisam Soheil Pour1 , Nader Shakeri 2, Khosrow Ebrahim1 , Farshad Ghazalian1
1- Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
2- Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran , nsporfsport@gmail.com
Abstract:   (2759 Views)
Introduction
Diabetes is one of the serious medical problems in recent years. The purpose of this study was to investigate the effect of six weeks’ endurance training and L-carnitine consumption on Bax / Bcl-2 and oxidative stress indices of heart tissue of diabetic rats.
Materials and Methods
In this experimental study, 45 male Wistar rats (weighing 20 ± 250 gr) were randomly divided into 6 groups including healthy control, diabetic control, sham, exercise, L carnitine and exercise and L-carnitine. Rats were diabetic peritoneally injected with nicotinamide at a dose of 95 mg / kg body weight and after 15 minutes of STZ injection of 55 mg / kg body weight. Rats receiving El Carnitine received daily 100 mg of l-carnitine orally. Aerobic exercises were performed for 5 weeks a week, from 9:00 to 11:00, for six weeks. The variables were measured by ELISA and ASA kits and in the heart tissue. One-way ANOVA and Tukeychr('39')s post hoc test were used to analyze the data using Shapiro Wylak test.
Results
The results showed that increasing endurance training and L-carnitine consumption had a significant effect on GPX (P = 0.001), MDA (P = 0.001), and Bax / Bcl2 heart rate (P = 0.001) in diabetic rats.
Conclusion
According to the findings of this study, the use of aerobic exercise and L-carnitine (in consultation with the physician) are recommended to reduce the complications of diabetes.
 
Keywords: Increasing endurance training, oxidative stress, diabetic rats, heart
Full-Text [PDF 1293 kb]   (365 Downloads)    
Type of Study: Orginal Article | Subject: Physiology
Received: 2019/07/3 | Revised: 2020/05/10 | Accepted: 2019/11/25 | ePublished ahead of print: 2019/12/10 | Published: 2020/05/10 | ePublished: 2020/05/10
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Soheil Pour M, Shakeri N, Ebrahim K, Ghazalian F. The effect of six weeks of increasing endurance training and consumption of L-carnitine on BAX / BCL-2 and oxidative stress indices in the heart tissue of diabetic rats. J Neyshabur Univ Med Sci. 2020; 8 (1) :46-59
URL: http://journal.nums.ac.ir/article-1-763-en.html


Volume 8, Issue 1 (Vol.8, No.1,Spring 2020) Back to browse issues page
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