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:: Volume 5, Issue 4 (Vol.5, No.4, Winter 2018) ::
J Neyshabur Univ Med Sci 2018, 5(4): 52-61 Back to browse issues page
Effect of 8 weeks aerobic training with cinnamon extract on retinol binding protein 4 (RBP4) and insulin resistance in rats fed with high-fructose
Ahmad Abdi 1, Parvin Farzanegi 2, Hajar Abaszade 3, Malek Habibi 4
1- Assistant Professor Islamic Azad University , a.abdi58@gmail.com
2- Associate Professor Islamic Azad University
3- Assistant Professor Islamic Azad University
4- MA Islamic Azad University
Abstract:   (574 Views)
Introduction
RBP4 is an adipokine that participates in insulin function and glucose metabolism. The elevated RBP4 serum levels were previously described in insulin-resistance states.  The aim of the present study was to investigate the effect of 8 weeks aerobic training and hydroalcoholic cinnamon extract on RBP4 and insulin resistance in rats fed with high-fructose.
Materials and Methods
In this experimental study thirty-six Wistar male rats were randomly divided into the four groups: control (n=9), training (n=9), cinnamon (n=9), and training–cinnamon (n=9). Insulin-resistance status induced by %10 fructose solutions during 5 weeks. Training groups subjected to a three-day per week aerobic training program for 8 weeks. The extract groups were fed 200 ml/kg/day cinnamon extract. The data were analyzed using one-way ANOVA and level of statistical significance was set at P<0.05.
Results
The results showed that aerobic training with or without the extract significantly decreased serum RBP4 (p<0.001). Also, in all the experimental groups significant decrease in serum insulin, glucose, and HOMA-IR, was observed (p=0.005, p=0.008 and p=0.001, respectively).
Conclusion
Based on the findings, aerobic exercises has beneficial effects on serum RBP4. It seems that the cinnamon extract has no effect on amelioration of insulin resistance through RBP4.
Keywords: Aerobic Exercise, Cinnamon Extract, RBP4, Insulin Resistance
Full-Text [PDF 919 kb]   (172 Downloads)    
Type of Study: Orginal Article | Subject: Physiology
Received: 2017/09/6 | Accepted: 2018/02/17 | Published: 2018/05/13
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Abdi A, Farzanegi P, Abaszade H, Habibi M. Effect of 8 weeks aerobic training with cinnamon extract on retinol binding protein 4 (RBP4) and insulin resistance in rats fed with high-fructose . J Neyshabur Univ Med Sci. 2018; 5 (4) :52-61
URL: http://journal.nums.ac.ir/article-1-400-en.html


Volume 5, Issue 4 (Vol.5, No.4, Winter 2018) Back to browse issues page
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