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Comparative study of antinociceptive effects of magnesium sulfate and lidocaine intra and postoperative surgery in animal model
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| Shahin Hajighahramani |
| Mohaghegh ardabili university , hajighahramani@yahoo.com |
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Abstract: (2552 Views) |
Introduction:
The aim of the present study was to evaluate the antinociceptive efficacy of three lumbosacral analgesic protocols for elective tail ducking surgery in dogs received acepromazine premedication.
Materials and methods:
15 dogs were randomly divided in 3 groups. Evaluated treatments were lidocaine (4mg/kg) alone (group1), magnesium sulphate (2.5 mg/kg ) in combination with lidocaine (4 mg/kg) (group2) and magnesium sulphate (2.5 mg/kg) alone ( group3) that were injected in the epidural space. Analgesia was assessed before surgical procedure using Von Frey device. Analgesia was evaluated during and after surgery, too.
Results:
The decrease of pain was significant in three treated groups during and after surgery (P < 0.05). Pain score was lower in first and second groups than in the third group, during surgery. There was a difference in pain score between first and second groups in postoperative evaluation (P < 0.05). Von Frey filaments evaluation showed that no significant changes in Von Frey thresholds were observed among the groups.
Conclusion:
Based on the present results it is concluded that magnesium sulfate injected into the lumbosacral epidural space of dogs causes to an antinociceptive effect in A δ and C- fibers without any motor functional deficits. Additionally, magnesium sulfate- lidocaine combination produce suitable postoperative analgesia. |
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| Keywords: Magnesium Sulfate, Lidocaine, Analgesia, Dog, Surgery |
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Full-Text [PDF 974 kb]
(208 Downloads)
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Type of Study: Orginal Article |
Subject:
Physiology
Received: 2017/08/17 | Accepted: 2018/01/10 | Published: 2018/03/5
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