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:: Volume 5, Issue 3 (Vol.5, No.3, autumn 2017) ::
J Neyshabur Univ Med Sci 2017, 5(3): 47-62 Back to browse issues page
Comparative study of antinociceptive effects of magnesium sulfate and lidocaine intra and postoperative surgery in animal model
Shahin Hajighahramani
Assisstant professor Mohaghegh ardabili university , hajighahramani@yahoo.com
Abstract:   (462 Views)
Introduction:
The aim of the present study was to evaluate the antinociceptive efficacy of three lumbosacral analgesic protocols for elective tail ducking surgery in dogs received acepromazine premedication. 
Materials and methods:
15 dogs were randomly divided in 3 groups. Evaluated treatments were lidocaine (4mg/kg) alone (group1), magnesium sulphate (2.5 mg/kg ) in combination with lidocaine (4 mg/kg) (group2) and magnesium sulphate (2.5 mg/kg) alone ( group3) that were injected in the epidural space. Analgesia was assessed before surgical procedure using Von Frey device. Analgesia was evaluated during and after surgery, too.  
Results:
The decrease of pain was significant in three treated groups during and after surgery (P < 0.05). Pain score was lower in first and second groups than in the third group, during surgery. There was a difference in pain score between first and second groups in postoperative evaluation (P < 0.05). Von Frey filaments evaluation showed that no significant changes in Von Frey thresholds were observed among the groups.
Conclusion:
 Based on the present results it is concluded that magnesium sulfate injected into the lumbosacral epidural space of dogs causes to an antinociceptive effect in A δ  and C- fibers without any motor functional deficits. Additionally, magnesium sulfate- lidocaine combination produce suitable postoperative analgesia. 
Keywords: Magnesium Sulfate, Lidocaine, Analgesia, Dog, Surgery
Full-Text [PDF 974 kb]   (68 Downloads)    
Type of Study: Orginal Article | Subject: Physiology
Received: 2017/08/17 | Accepted: 2018/01/10 | Published: 2018/03/5
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Hajighahramani S. Comparative study of antinociceptive effects of magnesium sulfate and lidocaine intra and postoperative surgery in animal model. J Neyshabur Univ Med Sci. 2017; 5 (3) :47-62
URL: http://journal.nums.ac.ir/article-1-408-en.html


Volume 5, Issue 3 (Vol.5, No.3, autumn 2017) Back to browse issues page
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