:: Volume 5, Issue 3 (Vol.5, No.3, autumn 2017) ::
J Neyshabur Univ Med Sci 2017, 5(3): 47-62 Back to browse issues page
Comparative study of antinociceptive effects of magnesium sulfate and lidocaine intra and postoperative surgery in animal model
Shahin Hajighahramani *
Mohaghegh ardabili university , hajighahramani@yahoo.com
Abstract:   (13905 Views)
The aim of the present study was to evaluate the antinociceptive efficacy of three lumbosacral analgesic protocols for elective tail ducking surgery in dogs received acepromazine premedication. 
Materials and methods:
15 dogs were randomly divided in 3 groups. Evaluated treatments were lidocaine (4mg/kg) alone (group1), magnesium sulphate (2.5 mg/kg ) in combination with lidocaine (4 mg/kg) (group2) and magnesium sulphate (2.5 mg/kg) alone ( group3) that were injected in the epidural space. Analgesia was assessed before surgical procedure using Von Frey device. Analgesia was evaluated during and after surgery, too.  
The decrease of pain was significant in three treated groups during and after surgery (P < 0.05). Pain score was lower in first and second groups than in the third group, during surgery. There was a difference in pain score between first and second groups in postoperative evaluation (P < 0.05). Von Frey filaments evaluation showed that no significant changes in Von Frey thresholds were observed among the groups.
 Based on the present results it is concluded that magnesium sulfate injected into the lumbosacral epidural space of dogs causes to an antinociceptive effect in A δ  and C- fibers without any motor functional deficits. Additionally, magnesium sulfate- lidocaine combination produce suitable postoperative analgesia. 
Keywords: Magnesium Sulfate, Lidocaine, Analgesia, Dog, Surgery
Full-Text [PDF 974 kb]   (547 Downloads)    
Type of Study: Orginal Article | Subject: Physiology
Received: 2017/08/17 | Revised: 2018/03/6 | Accepted: 2018/01/10 | Published: 2018/03/5 | ePublished: 2018/03/5

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Volume 5, Issue 3 (Vol.5, No.3, autumn 2017) Back to browse issues page