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Protective effect Aqueous Extraction of Red Crataegus pentaegyna after High Intensity Running Training on Cardiac Injury Biomarkers in Male rats
Ahmad Abdi Dr 1, Seyedeh maryam Mostafavian MS2 , Maryam Davaran MS2 , Tahereh Haeri MS3
1- Islamic Azad University , a.abdi58@gmail.com
2- Islamic Azad University
3- University of Mazandaran
Abstract:   (129 Views)
Introduction
The aim of the present study was to examine the Protective effect Aqueous Extraction of Red Crataegus pentaegyna after High Intensity Running Training on Cardiac Injury Biomarkers in Male rats.
Materials and Methods
Twenty Wistar male rats (4-6 weeks old, 140-173 g weight) were randomly classified into saline-control (SC), saline-training (ST), Crataegus-Pentaegyna -control (CPC), and Crataegus-Pentaegyna -training (CPT) groups. Training groups have performed a high-intensity running program (at 34 m/min, 60 min/day, 5 days/week) on a motor-driven treadmill for eight weeks. Animals were orally fed with Crataegus-Pentaegyna extraction (500mg/kg) and saline solution for six weeks. Seventy- two hours after the last training session, rats were sacrificed; hearts were excised and immediately frozen in liquid nitrogen and stored at -80 °C. Plasma also was collected for plasma variable measurements. Statistical analysis was performed using a one way analysis of variance, and significance was accepted at p < 0.05.
Results
The results showed that high intensity running significantly increased heart and plasma cTnI, LDH and CK in rats. Also heart and plasma cTnI, LDH and CK in a CPC was significantly decreased than ST group.
Conclusion
Our findings show that a Red Crataeguse-Pentaegyna was able to prevention Cardiac injury biomarkers in rats as a result of intensity endurance training.
Keywords: Cardiac Injury, Training, rats, Red Crataegus
     
Type of Study: Orginal Article | Subject: Physiology
Received: 2018/09/15 | Accepted: 2019/01/19
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