:: Volume 7, Issue 3 (Vol.7, No.3,autumn 2019) ::
J Neyshabur Univ Med Sci 2019, 7(3): 131-142 Back to browse issues page
The effect of silver nanoparticle toxicity on the inflammatory markers of heart tissue following an anaerobic training course in male wistar rats
Forogh Javaheri hoshi Dr1 , Asieh Abbassi daloii Dr * 2, Ahmad Abdi Dr1 , Seyed javad Ziaolhagh Dr3
1- Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
2- Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran. , a.abdi58@gmail.com
3- Department of Exercise Physiology, Shahrood Branch, Islamic Azad University, Shahrood, Iran
Abstract:   (1929 Views)

Exposure to nanoparticles toxicity leads to impairment of heart function and increases inflammatory cytokines. The purpose of this study was to investigate the effect of silver nanoparticle toxicity on the inflammatory markers of heart tissue following an anaerobic training course in male wistar rats.

Materials and Methods

In this experimental study, 30 male Wistar rats aged 8 to 12 weeks and weighing 202±34.9 gr were randomly divided into 6 groups include of control, anaerobic training, anaerobic training - nano biological, anaerobic training - nanochemical, nano-biological and nanochemical. Chemical and biological silver was injected intraperitoneally after a period of anaerobic training. The specimens were discarded after 48 hours, and the heart tissue was removed.

Results

The results showed that ICAM, hsCRP, IL-8 and IL-6 levels of male Wistar rats were different in groups (P=0.000). The hsCRP concentration of heart tissue was significantly lower in the Nanochemical - anaerobic and Nanobiological - anaerobic training group compared to Nanochemical and Nanobiological groups respectively (P=0.000). Also, IL-8 of heart tissue was significantly lower in the Nanochemical - anaerobic group compared to the Nanochemical group (P=0.000).

Conclusion

The toxicity of silver nanoparticles was associated with an increase in inflammatory markers in the heart tissue. It seems regular anaerobic training may have a protective effect against the increase some of the inflammatory factors due to the toxicity of chemical and biological silver nanoparticles.

Keywords: Silver Nanoparticles, Exercise, Inflammatory parameters, Heart Tissue, Rats
Full-Text [PDF 453 kb]   (216 Downloads)    
Type of Study: Orginal Article | Subject: Physiology
Received: 2019/06/15 | Revised: 2020/03/10 | Accepted: 2019/08/13 | ePublished ahead of print: 2019/08/26 | Published: 2019/12/22 | ePublished: 2019/12/22


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Volume 7, Issue 3 (Vol.7, No.3,autumn 2019) Back to browse issues page