[Home ] [Archive]   [ فارسی ]  
:: Volume 8, Issue 4 (Vol.8, No.4,Winter 2020) ::
J Neyshabur Univ Med Sci 2020, 8(4): 136-147 Back to browse issues page
Evaluation the effects of Teucrium polium hydroalcoholic extract on the fetus and chorioallantoic fluid using a chick embryo model
Amin Derakhshanfar Dr1, Hadi Tavakkoli Dr * 2, Javad Moayedi Mr1, Ali Poostforoosh Fard Dr1
1- Shiraz University of Medical Sciences
2- Shahid Bahonar University of Kerman , tavakkoli@uk.ac.ir
Abstract:   (220 Views)
Introduction
Side effects of drugs have always been controversial issues in medical science. To date, sufficient researches were not performed on the side and pathological effects of Teucrium polium as an herb in the fetus. Therefore, the present study aimed to investigate the pathological effects of Teucrium polium hydroalcoholic extract on chorioallantoic fluid composition, weight, growth, external and internal tissues of the fetus using a chick embryo model.
Materials and Methods
A total of 48 Ross 308 embryonated eggs were randomly divided into 3 equal groups. In the first group (control), 0.5 CC of phosphate buffer saline and the second and third groups, Teucrium polium hydroalcoholic extract with doses of 25 and 50 mg/kg egg-weight were inoculated into the eggs. Embryos were allowed to develop until day 18 and then examined for macroscopic and microscopic lesions.
Results
Injection of e hydroalcoholic extract caused a disturbance in the weight, growth, and biochemical factors of the chorioallantoic fluid during the growth period. The most pathological effects were observed in the brain, lung, heart, liver, and kidney of the embryos which received the Teucrium polium hydroalcoholic extract at a dose of 50 mg/kg.
Conclusion
Teucrium polium hydroalcoholic extract can produce various pathological effects in the external organ, internal organ, and the chorioallantoic fluid. Considering the consumption of this herb in different regions of Iran, it is recommended that its usage be taken with caution, especially during pregnancy.
Keywords: Histopathology, Herbal, Teucrium polium, Fetus, Chick
Full-Text [PDF 1545 kb]   (59 Downloads)    
Type of Study: Orginal Article | Subject: Pathology
Received: 2019/10/26 | Revised: 2020/12/21 | Accepted: 2020/06/14 | Published: 2020/12/21 | ePublished: 2020/12/21
Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Derakhshanfar A, Tavakkoli H, Moayedi J, Poostforoosh Fard A. Evaluation the effects of Teucrium polium hydroalcoholic extract on the fetus and chorioallantoic fluid using a chick embryo model. J Neyshabur Univ Med Sci. 2020; 8 (4) :136-147
URL: http://journal.nums.ac.ir/article-1-833-en.html


Volume 8, Issue 4 (Vol.8, No.4,Winter 2020) Back to browse issues page
مجله علوم پزشکی نیشابور J Neyshabur Univ Med Sci

*** هرگونه کپی برداری از این سایت بدون ذکر منبع غیر قانونی و همراه با پیگیری های قضایی می باشد *** مجله دانشکده علوم پزشکی نیشابور *** Any copying of this site without citing the source is illegal And is associated with the pursuit of justice ***

Persian site map - English site map - Created in 0.07 seconds with 30 queries by YEKTAWEB 4250